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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

v. 屈从,死
A型与B型人格理论指出,A型人格的人外向、野心勃勃、严谨、地位意识强、敏感、不耐烦、焦虑、积极主动和注重时间管理。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

The Crown
If 2017 was the year policymakers began to worry about the growth of the “precariat”, 2018 will be the year they try to do something about it.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

I wish you a happy New Year. All affection and best wishes to you and yours.

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 广西水泥抽查4批次不合格
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

SETTING: This house is on Modena Island, about 20 miles from downtown Savannah. According to the listing agent, the community is gated and has about 20 houses sited amid live oaks and saltwater marshes. Modena Island is a part of Skidaway Island, which has an oceanography research facility operated by the University of Georgia and a large state park.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Michael Na表示,尽管韩国已经和中国签署了贸易协议,中国政府仍有足够多的其他方式惩罚韩国政府。
这是继2016年我国首次同步调整企业和机关事业单位退休人员的基本养老金水平后,我国再次做出同步调整。
延长的生育假如何落实往往由地方政府决定。国家层面应该颁布执行细则以及具备法律约束力的相关措施,以确保该政策的贯彻实施和合理执行,从而保证女性不因劳动成本最小化而受到雇主的歧视。
"Micro blogs and other new media give everyone a speaking platform. If you cannot face the criticism and cooperate with the public, you cannot work well." ZHAO BAIGE, NPC deputy and executive vice-president of the Red Cross Society of China

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 门窗五金行业追求“低碳热”
Perspective

Trends and targets in antiviral phototherapy

Wonder Woman
It makes piggybacks more comfortable.
James Bond Themes 1. "Goldfinger" by Shirley Bassey
Only two people know the Oscars winners list and supervise the counting procedures - PwC tax adviser Martha Ruiz and Brian Cullinan an accountant.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

10. China watchers inthe United States will continue to postulate China’s declining growth rate inthe face of evidence that it is stable at over 7%. China will grow fasterin 2014 than in 2013.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

罗宾威格尔斯沃思(Robin Wigglesworth)

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

n. 罪犯
The 1.48 million people who qualified to take the exam marked an increase of 90,000 over last year, while the number of positions offered - 27,000 - remained almost the same.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Stand: Starbucks CEO Howard Schultz urged the end of government shutdown
But if the U.S. can avert that Washington-made crisis, the outlook for workers finding jobs is actually looking pretty good for next year. For one thing, the damage of superstorm Sandy will have to be repaired, meaning jobs in construction and retail. Businesses, meanwhile, which have held off investing and hiring because of uncertainty over the fiscal outlook, might finally open their wallets. That means more jobs, too.[qh]

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

马特达蒙凭借他在《火星救援》中扮演的被困宇航员一角而荣获喜剧类最佳男主角奖项。
Though its campuses often steal the benefits spotlight -- with their outdoor sports facilities, free food and more -- there's a more morbid perk that should certainly be noted. If a U.S. Googler passes away while working for the tech giant, the employee's spouse or domestic partner receives 50% of the deceased's salary, no matter how long or short his tenure, every year for the next decade.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

今年初,麦基在接受媒体采访时说:“虽然似乎有悖于直觉,但尽可能提高长期利润的最佳途径就是不要把利润作为公司的首要目标。”
……声称自己之所以迟到是因为迷路了,但我们的接待员却说她刚刚看到这位求职者在咖啡店里玩。
Strong in many categories, but without quite managing to be a front runner in any. Perhaps Timothee Chalamet's performance is its best chance of awards success.
SIZE: 5,003 square feet total

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
From the themed collection: 公积金月缴存额下月起上调
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

Quantum Break

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

10.Fears of Another Tsunami
We learned about the lingering toll of this frightening epidemic.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

I am calling this the Wan Long prize, after the Chinese meat magnate who once uttered the clearest sentence ever spoken by a CEO: “What I do is kill pigs and sell meat.” Mr Wan will surely approve of my winner, a BNSF railway executive who told a conference: “We move stuff from one place to another.”

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

在好莱坞完成一系列高调收购的娱乐业大亨王健林、以及互联网巨头马云(Jack Ma)分别以321亿美元和306亿美元的财富,保住了他们在榜单上的头名和次名位置。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

而今年的诺贝尔奖,更是一反过往青睐大型科技成果的传统,将大奖颁给了体积最小的科学新发现。
The Bloomberg soft commodities index has gained 21 per cent, compared with 24 per cent for industrial metals and 1.5 per cent for energy.
5. 2012年搞笑诺贝尔奖之化学奖
年末城镇登记失业率4.02%,为多年来最低;

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

去年年末,世界卫生组织宣布,寨卡病毒不再是全球紧急公共卫生事件。然而,人们才刚刚开始认识到这种病毒对婴儿及其未来几十年生活的影响。在巴西东北部,人们首次发现了病毒与小头畸形等出生缺陷之间的联系,家庭竭力为患病婴儿提供最好的生活。研究人员希望通过研究在巴西出生的一对双胞胎,来寻找病毒对胎儿影响的线索。这对双胞胎中,一个有出生缺陷,另一个没有。
One highlight of last year's box office was seven high-quality domestic films listed on the top 10 earners, including 'Monster Hunt', a live-action hybrid, and 'Monkey King: Hero is Back', a 3D animation based on the classic ancient story.
联想首席执行官杨元庆
科派斯塔克表示,东京回归榜首并不让人惊讶,因为东京的高工资推动了物价的上涨,房价和房租也很昂贵。
Today, the Financial Times reveals the fake gross domestic product data routinely released from many northern Chinese regions. There, solid alternative evidence suggests the authorities have “smoothed” the economic growth figures. They artificially boosted growth figures between 2012 and 2016, masking a real downturn, and last year covered up a genuine recovery.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

The Caixin-Markit manufacturing purchasing managers’ index dipped to 50.8 in November, down from 51 in October and coming closer to the 50-point threshold that delineates expansion from contraction. A median forecast from economists polled by Reuters had predicted a fall to 50.9.
Movies in 2016 are going to be huge and there's going to be a lot of them. Some of the best movies coming in 2016 include,Batman vs Superman: Dawn of Justice, Captain America: Civil War, Fantastic Beasts and Where to Find Them, Finding Dory, Rogue One: A Star Wars Story, X-Men: Apocalypse, Independence Day: Resurgence, WarCraft and Suicide Squad.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

The rest of the top 10 2016 highest-paid actresses are:

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Bingo! In fewer than 20 words it combined five previous years’ winners, only to say nothing at all. With a heavy heart, I award eBay my overall Golden Flannel Award for 2016.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Capsized ship righted
福布斯杂志认为,特朗普净资产的下降,主要是由于曼哈顿市中心房地产市场的疲软。
艾瑞咨询集团和中国最火的微博平台——新浪微博在上海的一个论坛上发布了该报道。该论坛由微博和通信巨头华为联合举办。
Prices at China's factory gates fell for a 34th consecutive month in December, pushed down by falling energy and commodity prices.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

超级大碗
vi. 流通,循环,传播
据《北京晚报》报道,最近公布的《凯度中国社交媒体影响报告》显示,由于社交媒体的负面影响,在1990年后出生的中国年轻人中,已有40%的人关闭了社交媒体应用的消息提醒功能。
Cross-cultural Instrumental performance (Yanni, USA, and Chang Jing)

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

老实说,如果你想观看一部让你大笑不停的网飞原创影片时,请去看《不可思议的杰西卡?詹姆斯》,因为这部轻松浪漫的喜剧片会让你笑到爆。
"Some geniuses in the internet industry created miracles, but that does not tell the whole story," said Chen. "Business has its own rules. Before you start up, you have to know how to produce products, how to sell them, how to manage a company. Those lessons you cannot expect a fresh graduate to know."

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 房企主打“现金为王”
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

At least 120 million American voters had been expected to cast votes in the race between the Democratic incumbent and Romney after a campaign focused on how to repair the ailing U.S. economy。
In early 2005, Stone and her co-founders Elisa Camahort Page and Jory Des Jardins noticed that there were countless women blogging, but mainstream media rarely linked to their posts. The trio decided to host a grassroots conference that year and attracted sponsors like Google and Yahoo. It quickly sold out and soon after, they launched BlogHer.com. The publishing platform turned blogging into a lucrative business for many women -- it paid $25 million to 5,000 of its bloggers between 2009 and 2012 -- and now reaches an audience of 92 million.
China's movie box office revenue rose 13.45 percent in 2017 to more than 55.9 billion yuan (8.6 billion U.S. dollars), with domestic films contributing 53.84 percent to the market, according to the State Administration of Press, Publication, Radio, Film and Television.
If you think Kevin Durant is scrawny now, just take a look at his tiny physique back when he played at Montrose Christian.
A number of nude photographs have been leaked online after several female students offered the photos in exchange for high-interest loans via an online lending platform.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

2. Dunkirk
enter进入+prise进入抓住[目标]→事业;进取心
反对派是合法的,可以自由表达观点而且权力受到限制。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

最糟糕地利用社交媒体奖
The other two tweets from Obama that made the list were posted when he was leaving the office.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 工业陶瓷企业的电商转型之路
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

另一方面,世界杯作为体育盛事和文化体验也成为了热门搜索项。
当然这也并不是说,你害怕老板起疑心,就要放弃你在领英上面的简介。但是告诉你,得小心点。其中一点是关掉你的活动广播这样你每一次策略性的行动就不会被所有网民发现,下面教你怎么做,在主页面,光标停在右上角,点击个性设置,在个性设置里面点击活动广播。
David said: ‘It was wonderful, you couldn’t fault it. It was perfection.’

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

4. 《卡罗尔》(Carol)。这是托德·海因斯(Todd Haynes)第一次执导不由自己编剧的影片,编剧菲丽丝·奈吉(Phyllis Nagy)简化了派翠西亚·海史密斯(Patricia Highsmith)的小说原著,海因斯藉此再次证明,电影导演不必依靠拍自己亲自写的剧本才能成为伟大导演,这个真理却遭到许多雄心勃勃或功成名就的导演忽略。
2017年,人们指责大型科技公司太过强大、利用自身的规模主宰市场,而且不够关注他们所创造的工具如何被用来做恶。
通常冷静的分析师们早已习惯了汽车行业的缓慢增长,但是遇到特斯拉,他们就丢掉了一贯的谨慎。德意志银行(Deutsche Bank)的分析师罗德o拉切给该股设定了310美元的目标价格。无独有偶,摩根士丹利(Morgan Stanley)的分析师亚当o乔纳斯也将特斯拉的目标股价定为320美元,并称它是“世界上最重要的汽车公司”。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

根据研究机构Millward Brown编制的BrandZ最新排行榜,全球100个最具价值品牌的品牌价值仍远远领先于其他品牌,今年它们的总价值上升3%,至3.4万亿美元。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

Will Zimbabwe’s new leader hold — and win — fair elections

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

几家大型对冲基金的资产规模,占据了该行业的大半江山。各家的回报率相差巨大。每个像威廉o阿克曼旗下潘兴广场那样的大赢家,都对应着一个像约翰o保尔森旗下优势基金那样的大输家。投资者选择对冲基金,是冲着其“非相关收益”,意即与大盘走向背道而行的趋势。今年,他们绝对是获得了“逆市”的收益,可惜是在大盘表现出色的情况下“逆市”。
charm(n 吸引力;(女人的)魅力)

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

China hopes that the Asia-Pacific region will be one that enjoys order and stability, a region that is able to work out issues through consensus-building consultation, properly manage differences through dialogue and has the wisdom to resolve differences.
我们对已经达成或者希望达成的一些区域贸易安排一直持开放态度,也乐见其成。只要是有利于贸易自由化的,我们都会去参与、去推进。
Two days ago here in Brazil, we were shocked when we spent some time with some children living on the streets. And this is what one child told us: "I wish I was rich and if I were, I would give all the street children food, clothes, medicine, shelter and love and affection." 在巴西,我被2天前见到的情景震惊了,那时我和当地的小孩在玩耍,其中一个小孩说:“我希望我能富裕起来,然后我会给这个街道所有的小孩饭吃,给他们衣服穿,医疗,住房和爱”。
报告发现,三线城市是最适合居住的地方。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Ranking third on our Top-Grossing list is Steve Carell. Despicable Me 2 was a huge hit this year, bringing in $919 million at the box office. Overall, the franchise has earned $1.4 billion at the box office worldwide and a third movie, Minions, is on the way. Carell also appeared this year in the small indie The Way Way Back and The Incredible Burt Wonderstone. The latter failed to earn back its production budget at the box office but we’re only looking at ticket sales here — the film put another $22.5 million in Carell’s column for 2013.
The relocation is also part of the integration plan for the Beijing-Tianjin-Hebei cluster, which aims to ease congestion in the capital and achieve more balanced development in the region.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 首部木门窗国家标准将实施
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

As the socialite arrived at Kylie Jenner's 19th birthday party in August she alighted her sports car in such a cack-handed (cack-legged, I suppose) way that meant that more was glimpsed than intended.
At a minimum, it is impossible for most people to get to work in the city, which affects the locus of several industries, including finance, advertising, healthcare and the arts. The city's transportation lines, bridges, and tunnels were shut down for nearly two days, and at the latest report, the subways may be down well into next week.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

The workers, who were part of a crew building a football stadium, were taken in the mainly Shi'ite Habibiya district in northeastern Baghdad.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

[.di:m?'gr?fik]
SplashData公司首席执行官摩根-斯莱恩说:“不幸的是,虽然最新的一部星球大战系列电影很精彩,但使用‘starwars’这个密码却很危险。”
南韩的活动分子在星期二发誓,要在月底通过宣传气球跨越边境向北韩偷运荷里活讽刺片"刺杀金正恩",以作为对北韩不断威胁的反抗。
13. 还有更好的。10月,《洛杉矶时报》报道,平等工作机会委员会正在调查这个行业内的性别歧视现象,美国民权同盟要求各州与联邦机构继自己之后各自进行调查。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
From the themed collection: 3月租房旺季 需求强劲租金企稳
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

“不能再采取某些国家先行动,其他国家随后行动的策略,因为时间不多了,”奥斯陆国际气候与环境研究中心(Center for International Climate and Environmental Research)的科学家格伦·P·彼得斯(Glen P. Peters)说。他也参与了这些新数据的编制。“现在需要大家齐心协力。”
For democrats, the outburst of such primal emotions is disturbing because they are so hard to contain.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

“有个女员工打包好自己的东西就一言不发地走了。”
Star Wars: Rogue One is set to release on December 16, 2016.
The Caixin-sponsored series is based on a much smaller sample of private companies than the official PMI reading, which focuses on larger state enterprises, and tends to be more volatile.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

[?'pi?r?ns]
勇士的横扫,实际上让那些试图挑战勇士的球队无力追赶勇士的脚步,致使联盟在季后赛收入上损失惨重。于是,总决赛便成了战胜勇士的最后的希望,也是最后的机会。总有些愚蠢的人通过不断告诉你不要低估了勒布朗·詹姆斯来让你重燃希望。我看了所有五场詹姆斯在的总决赛,我现在客观的告诉你:詹姆斯知道自己赢不了。“我能做什么?他们赢了73场比赛,我打败了他们,于是他们引进了凯文杜兰特。”在凯文杜兰特用自己的冷血投射杀死系列赛之前,骑士还设法在三场比赛中夺得了一场胜利。但最后,骑士队虽然避免了横扫的尴尬,但他们结束赛季的方式也只能用虎头蛇尾来形容。
shatter

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

About 40 per cent of entrepreneurs did not seek any help when securing finance. Half of these raised equity purely from their own savings and/or family and friends compared with only 40 per cent of those who sought help from the school or alumni network.
['t?]

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

马科斯卡瓦略是一名18岁的巴西球迷,本周早些时候,在巴西利亚国家体育馆闲逛的他表示:“我们甚至压根就没想过买票这事。门票太贵了,我们根本买不起,能做的也就是在家看看球了。我们看着去那些现场观战兴高采烈的人们,但我们自己却去不了,这真令人难过。”
2016年奥运会和2014年足球世界杯主办城市里约打败了希腊,成为搜索次数最多的旅游目的地。
订婚买钻石真是太没新意了

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

['l?sti?]
民粹主义的兴起(即使在美国和英国这样的就业人数众多的国家也是如此)使得政客们认识到,就业的质量和数量同等重要。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

土耳其副总理库尔图尔姆斯说,土耳其当局与伊拉克方面保持着接触。
It can transport rows of seedlings in minutes. And can reduce planting time by 88 percent.
伞上的链子可以系在狗狗的项圈或背带上。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

过去三年,由于北京决定在官方总收入中增加新的服务费,有关中国票房增长的结论变得复杂起来。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

在完成作业不久之后,孙轶萧就听到外面嘈杂的响声。
And a few stopped to change a tire for an elderly French couple.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

consistently
Although Facebook is blocked in China, Tencent has linked WeChat to Facebook, which means that users outside of China can use the service in conjunction with the world's most popular social network. That is a boon for WeChat in Southeast Asian countries like Indonesia, Thailand and the Philippines, which have large numbers of Facebook users. Tencent has offered WeChat in languages for all three markets.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

和所有大学生一样,埃文o雷喜欢使用表情符号。但让他恼火的是,没有什么表情符号能够让他向圣母大学的同学表达自己对该校橄榄球队战斗的爱尔兰人的自豪感。于是,他和肖恩o欧布莱恩一起创办了一桩小生意,以弥补这一空白。这款名为TextPride的产品从体育和娱乐世界中获得图像授权,然后将其打包成贴纸出售。比如,在Kik这样的短信应用中,用户可以花1.99美元买一包迪斯尼电影《冰雪奇缘》的贴纸。
该校学员们称赞这里的训练将他们推出了自己的“舒适区”,还有针对他们各自企业情况量身定制的一对一辅导课程。“对于什么是优秀的领导,这里打开了我们的视界,”一位学员说,“我们先了解自己,了解我们的动力所在以及为什么,这样才能管理别人。”

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

“我想,在21世纪,人们绝对会质疑这件事。”
At the end of a politically charged ceremony in which Donald Trump was the subject of frequent jokes by host Jimmy Kimmel, Warren Beatty and Faye Dunaway announced that La La Land had won. But as the producers and cast of Damien Chazelle’s modern musical were on stage giving emotional thank you speeches, they were told that Moonlight was the real winner.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

“Airbnb is here to stay,” Mr. Gottsegen said. “Instead of fighting it, we should wrap our arms around it and make it better.”

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

单词exceed 联想记忆:
"Last year, 1.2 million Chinese visited Australia. We anticipate this will grow during the China-Australia Year of Tourism and will continue to grow afterward."
Typically, he writes, analysts “see the root cause of emerging markets’ susceptibility to crises in weak institutions that make countries vulnerable to economic and financial instability.”
When a cup is placed on a dispenser, a magnet lifts to let beer flow in.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

他说,“油价将波动上行。”

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 沈阳工业企业制造成本普降20%以上
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Stevens会演唱电影《以你的名字呼唤我》中《Mystery of Love》,以及Bernal, LaFourcade和 Miguel会合唱《寻梦环游记》中的歌曲《Remember Me》。
哈佛大学连续16年位居榜首,斯坦福大学和剑桥大学仍分别位列第二、第三名。
A 19-year-old girl, referred to as Guo Lingling (this may be a pseudonym), was allegedly struck and kicked repeatedly by her so-called instructors after failing to ask permission to go to the bathroom. An autopsy report showed she died from skull injuries and brain damage.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Xi Jinping and other leadershave made it clear that China is willing to accept a slower growth pace if thiswill allow for a more sustainable, consumer-driven expansion of its economy.Some prognosticators are quick to conclude that China’s economy will soonsignificantly slow down, especially because China’s economy has sputteredfollowing prior instances when the nation’s leaders have effected suchfundamental economic reforms (such as in 1978 and 1993).
全国31个省(区、市)1767所高校43万多名学生接受了调查。89.2%的受访者曾考虑过创业,18.2%的受访者称有强烈的创业意向。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

There are a wide range of low-cost flights to Russia and transportation in the country is also easy with the Trans-Siberian Railway.
We think of the passage of NBA time in seasons, for obvious reasons. There's connection, a continuum. It's how we remember things that happen, in the course of a season of play. But there's some benefit to looking back at a calendar year, January 1 to December 31, and what we've learned in that process. After all, many say the "unofficial start" to the NBA season is Christmas, with the new year starting soon after. So here are the lessons we learned about the NBA in the year 2017.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

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Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Lisa Stone
A retrospective section will include movies produced by the Shanghai studio Wenhua, a company founded in 1946 that ushered a new era of Chinese art-house films, Zhang said, giving viewers "a glimpse of Chinese cinematic culture and history".
在几代人之中,工薪阶层的白人受到双重赐福:他们既拥有种族所带来的特权地位,也受惠于经济的繁荣发展。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

南韩的活动分子在星期二发誓,要在月底通过宣传气球跨越边境向北韩偷运荷里活讽刺片"刺杀金正恩",以作为对北韩不断威胁的反抗。
Any decision by China’s policymakers to begin selling down the country’s huge reserves would have a large impact on markets.
后来,通用汽车在1958年设计出一款无人驾驶汽车,其原理是:由线圈感知道路中所嵌入电线的交流电信号,并相应地调整方向盘。然而汽车确实能自主驾驶,但并不能称为第一辆全自动驾驶汽车,因为它必须依赖嵌在地面的电线。在日本的筑波机械工程实验室,津川和他的几个同事发明了世界上第一辆自动驾驶汽车。然而,德国工程师恩斯特·迪克斯被称为无人驾驶汽车的先驱。1987年,他发明的"极速",时速超过90千米(56英里/小时),行驶了大约20千米(12分钟)。7年后,他发明的VaMP,不但可以识别道路标记,而且能定位自己在车道内的位置,还能勘测其他车辆,甚至能判断何时该变道。一年后,他和他的团队发明的自动驾驶汽车,从德国行驶到丹麦,最高时速为180千米(111英里/小时)。整段旅程中,仅有5%左右的路程是人为驾驶。
大多数汇款出自美国(1170亿美元)、欧洲(1150亿美元)和海湾国家(1000亿美元)。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

这座墓地在2007年7月份的时候首次被发现,由新疆文化遗产和考古研究院负责开挖,挖掘工作得到当地政府的支持。研究团队将他们的发现发表在了中国的期刊《文物》上。这篇文章最近被翻译成英语,并发布在了《中国文化遗迹》杂志上。
再见,卡西尼号

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
From the themed collection: 2014家居销售更注重客户体验
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

While the FT online and full-time MBAs are not strictly comparable because the criteria used to judge them are slightly different, it is interesting to note that IE and Warwick Business School are among six schools to feature in both rankings.
discourse
[in'spai?ri?]

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

The clothespin dates back to the 1800s, but in 2016 it became "smart." Meet Peggy, the laundry peg that's supposed to "help you lighten the load" by telling you when the washer cycle is over and if the weather is nice enough to hang your clothes outside. The device connects to your phones and sends you alerts when the weather changes or when you need to remove your clothes.
1. Beyoncé “Beyoncé” (Parkwood Entertainment/Columbia) An ambush that landed after last year’s tabulations, Beyoncé's tour de force — a lustrous showcase of soulful dominion, sleek production, sensual abandon and feminist agency, not always in that order — kept its relevance during a long year swollen with distractions. The singing, like the attitude, is phenomenally assured yet full of nuance; the message is complicated but clear. It’s high-wire pop that refuses to pander.

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